Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine
Identifieur interne : 005170 ( Main/Exploration ); précédent : 005169; suivant : 005171Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine
Auteurs : Yuxian He [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Shuwen Liu [États-Unis] ; Zhihua Kou [République populaire de Chine] ; Wenhui Li [États-Unis] ; Michael Farzan [États-Unis] ; Shibo Jiang [États-Unis]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Anticorps (), Cytométrie en flux, Fragments d'immunoglobuline (), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Humains, Immunoglobuline G (), Lapins, Lignée cellulaire, Plasmides (métabolisme), Protéines de fusion recombinantes (), Protéines de l'enveloppe virale (), Relation dose-réponse (immunologie), Structure tertiaire des protéines, Test ELISA, Vaccins ().
- MESH :
- métabolisme : Plasmides.
- Animaux, Anticorps, Cytométrie en flux, Fragments d'immunoglobuline, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Immunoglobuline G, Lapins, Lignée cellulaire, Protéines de fusion recombinantes, Protéines de l'enveloppe virale, Relation dose-réponse (immunologie), Structure tertiaire des protéines, Test ELISA, Vaccins.
English descriptors
- KwdEn :
- Animals, Antibodies (chemistry), Cell Line, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunoglobulin Fragments (chemistry), Immunoglobulin G (chemistry), Membrane Glycoproteins (chemistry), Plasmids (metabolism), Protein Structure, Tertiary, Rabbits, Recombinant Fusion Proteins (chemistry), Spike Glycoprotein, Coronavirus, Vaccines (chemistry), Viral Envelope Proteins (chemistry).
- MESH :
- chemical , chemistry : Antibodies, Immunoglobulin Fragments, Immunoglobulin G, Membrane Glycoproteins, Recombinant Fusion Proteins, Vaccines, Viral Envelope Proteins.
- metabolism : Plasmids.
- Animals, Cell Line, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Protein Structure, Tertiary, Rabbits, Spike Glycoprotein, Coronavirus.
Abstract
The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (CoV), a type I transmembrane envelope glycoprotein, consists of S1 and S2 domains responsible for virus binding and fusion, respectively. The S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. Here we show that a recombinant fusion protein (designated RBD-Fc) containing 193-amino acid RBD (residues 318–510) and a human IgG1 Fc fragment can induce highly potent antibody responses in the immunized rabbits. The antibodies recognized RBD on S1 domain and completely inhibited SARS-CoV infection at a serum dilution of 1:10,240. Rabbit antisera effectively blocked binding of S1, which contains RBD, to ACE2. This suggests that RBD can induce highly potent neutralizing antibody responses and has potential to be developed as an effective and safe subunit vaccine for prevention of SARS.
Url:
DOI: 10.1016/j.bbrc.2004.09.106
PubMed: 15474494
PubMed Central: 7092904
Affiliations:
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Le document en format XML
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Kimball Research Institute, New York Blood Center, New York, NY 10021, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Immunology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular Biology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Molecular Biology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name><affiliation wicri:level="2"><nlm:aff id="aff1">Viral Immunology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Immunology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kou, Zhihua" sort="Kou, Zhihua" uniqKey="Kou Z" first="Zhihua" last="Kou">Zhihua Kou</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Molecular Biology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Molecular Biology, Beijing Institute of Microbiology and Epidemiology, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Medicine, Partners AIDS Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Partners AIDS Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Medicine, Partners AIDS Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Partners AIDS Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="2"><nlm:aff id="aff1">Viral Immunology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Immunology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Biochemical and Biophysical Research Communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies (chemistry)</term><term>Cell Line</term><term>Dose-Response Relationship, Immunologic</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Flow Cytometry</term><term>Humans</term><term>Immunoglobulin Fragments (chemistry)</term><term>Immunoglobulin G (chemistry)</term><term>Membrane Glycoproteins (chemistry)</term><term>Plasmids (metabolism)</term><term>Protein Structure, Tertiary</term><term>Rabbits</term><term>Recombinant Fusion Proteins (chemistry)</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines (chemistry)</term><term>Viral Envelope Proteins (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps ()</term><term>Cytométrie en flux</term><term>Fragments d'immunoglobuline ()</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires ()</term><term>Humains</term><term>Immunoglobuline G ()</term><term>Lapins</term><term>Lignée cellulaire</term><term>Plasmides (métabolisme)</term><term>Protéines de fusion recombinantes ()</term><term>Protéines de l'enveloppe virale ()</term><term>Relation dose-réponse (immunologie)</term><term>Structure tertiaire des protéines</term><term>Test ELISA</term><term>Vaccins ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies</term><term>Immunoglobulin Fragments</term><term>Immunoglobulin G</term><term>Membrane Glycoproteins</term><term>Recombinant Fusion Proteins</term><term>Vaccines</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plasmids</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Plasmides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Dose-Response Relationship, Immunologic</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Flow Cytometry</term><term>Humans</term><term>Protein Structure, Tertiary</term><term>Rabbits</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps</term><term>Cytométrie en flux</term><term>Fragments d'immunoglobuline</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Humains</term><term>Immunoglobuline G</term><term>Lapins</term><term>Lignée cellulaire</term><term>Protéines de fusion recombinantes</term><term>Protéines de l'enveloppe virale</term><term>Relation dose-réponse (immunologie)</term><term>Structure tertiaire des protéines</term><term>Test ELISA</term><term>Vaccins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (CoV), a type I transmembrane envelope glycoprotein, consists of S1 and S2 domains responsible for virus binding and fusion, respectively. The S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. Here we show that a recombinant fusion protein (designated RBD-Fc) containing 193-amino acid RBD (residues 318–510) and a human IgG1 Fc fragment can induce highly potent antibody responses in the immunized rabbits. The antibodies recognized RBD on S1 domain and completely inhibited SARS-CoV infection at a serum dilution of 1:10,240. Rabbit antisera effectively blocked binding of S1, which contains RBD, to ACE2. This suggests that RBD can induce highly potent neutralizing antibody responses and has potential to be developed as an effective and safe subunit vaccine for prevention of SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. 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Conley</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de New York</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name></region><name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></noRegion><name sortKey="Kou, Zhihua" sort="Kou, Zhihua" uniqKey="Kou Z" first="Zhihua" last="Kou">Zhihua Kou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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